Eoin Morgan and Chris Tremlett could make their ICC World Cup entrance as England take on co-hosts Bangladesh in their penultimate group fixture.
England’s topsy-turvy form in the competition so far leaves them with five points from four matches and potentially one victory away from a quarter-final berth.
The squad has been disrupted since their last outing - the six-run win over South Africa - as Stuart Broad and Kevin Pietersen have both departed with injuries.
While Morgan’s return to the squad has been met with widespread relief, Pietersen’s absence causes a major headache as to who should partner Andrew Strauss at the top of the order.
Tremlett’s application to replace Broad has been approved by the ICC but he is likely to be behind Ajmal Shahzad or James Tredwell in the pecking order for the Bangladesh tie.
England will have to reshuffle their line-up for the match, with no obvious like-for-like replacement available for Pietersen or Broad.
The issue of Strauss’ opening partner is a tricky call for the selectors.
The late decision to try Pietersen at the top of the order in the World Cup had been a success with the pair putting together partnerships of 105, 68 and 91 in the opening three games.
But with Pietersen out, one of Ravi Bopara, Matt Prior, Jonathan Trott or Ian Bell may move up the order.
There have even been some calls for spin bowler Graeme Swann to play as a 'pinch hitting' opener.
Typically, Strauss has kept his cards close to his chest in the build-up, leaving the media and supporters guessing as to England's intentions.
The pitch in Chittagong is likely to favour spin bowlers, meaning Tredwell could be in line for a first World Cup appearance.
England have opted for two spinners since their disappointing opening performance against Netherlands with Mike Yardy taking the second role - alongside Swann.
With spin such proving such an important weapon in the tournament so far, the chance to test Tredwell could prove tempting.
Shahzad or Tremlett, who has been with the squad throughout, would come in should England wish to keep the same balance. Paul Collingwood might also get a chance.
Bangladesh are under immense pressure after capitulating to 58 all out in their last match against the West Indies.
With just one narrow win against Ireland to their name so far, Shakib Al Hasan’s side are in real danger of crashing out of the World Cup in the group stage.
Their brittle batting, largely dependent on Tamim Iqbal who's on the Lord’s Honours Boards, remains a major concern.
With a host of spin options though, fronted by Shakib, the Tigers can still prove a tricky proposition on their home pitches and were unlucky to lose 3-0 when the sides met in a One Day series in Bangladesh last year.