MCC West South West take on MCC South in a timed game at Lord's on Tuesday 24 April, with entry to the match free for all.
The MCC West South West team will be captained by Old Bristolians Westbury seamer Gareth Griffiths.
Griffiths, who is the South West area representative manager for MCC, recently made his 100th appearance for the Club but has not played at Lord's before.
He said: “Something like 120 players from Gloucestershire, Somerset, Wiltshire, Devon, Cornwall and even London applied to play in this game.
“It’s a fantastic honour and an opportunity that won’t come along very often.”