Middlesex host newly promoted Derbyshire in the first match at Lord's in 2013 with England fast bowler Steven Finn available for selection.
The season kicks off at the Home of Cricket with championship contenders Middlesex looking to carry on their winning-ways after a convincing 10-wicket thumping of Nottinghamshire last week.
It was a highly impressive start to the campaign for Angus Fraser's side, who finished third last summer and have been identified as a side who could go all the way this year.
Their squad shows just one change, with Finn replacing new signing James Harris, who picked up a hamstring strain during a frustrating debut at Trent Bridge.
Lord's is set for pleasant conditions throughout the first game of the year, in contrast to the unseasonably cold weather which has plagued the country so far this season.