Middlesex remain behind the eight-ball in their LV= County Championship clash against Derbyshire after their top-order misfired on day two.
Starting their first innings after bowling the hosts out for 385, the Panthers were 197/6 at the close, still 33 runs short of the follow-on target and having relied on an unbeaten 43-run partnership between Ollie Rayner and John Simpson to partially dig them to safety.
Adam Voges made 69 but three wickets for Matt Higginbottom pegged the title chasing visitors back at regular intervals.
Wayne Madsen had earlier finished with 138 not out for Derbyshire, after resuming on 105 overnight, while Tim Groenwald added to Middlesex's frustration by smacking nine fours in a 48-ball 49 from number 10.
Tim Murtagh finished with figures of 3/63.