Toby Roland-Jones took a hat-trick and Tim Murtagh five wickets as Middlesex dismissed Derbyshire for just 60 on their way to a crushing nine-wicket win at Lord's.
Middlesex continued their faultless start to the season with a relentless display of seam bowling strength in Derbyshire's second innings.
After conceding a first-innings deficit of 16 to the newly promoted visitors in the morning session, Angus Fraser's much-vaunted pace-attack flexed their muscles in destructive style.
Murtagh has had a quiet start to the season by his high standards, but got in on the act with a magnificent spell of high-class swing bowling, picking up five of the first six wickets to fall.
Whereas Nottinghamshire were criticised for poor shot selection at Trent Bridge last week, Derbyshire can at least point to the quality of Murtagh's stint from the Nursery End when they pick over the pieces of their innings.
The Ireland international attacked the stumps, claiming three LBWs and one bowled, before Jonathan Clare gifted him his fifth when he wafted a wide one to second slip to leave Derbyshire 26/6.
With Shivnarine Chanderpaul looking solid at one end, Murtagh might have expected to be called upon to finish the job off later on.
But after the slightly expensive Steven Finn (2/34) dismissed Tom Poynton, Chanderpaul was left to look on helplessly from the non-striker's end as Roland-Jones finished off the innings with three-from-three - Mark Turner's demolished off-stump reflective of Derbyshire's day.
Middlesex lost Sam Robson for a duck in their chase as the wickets continued to tumble.
But Joe Denly quickly settled any home nerves with some positive stroke-play - including a six into the Grand Stand - and for the second week running captain Chris Rogers was there to see home the victory.